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. 2004 Feb;164(2):689–699. doi: 10.1016/S0002-9440(10)63156-2

Figure 4.

Figure 4

Protein expression of DNMT1 and DNA methylation profiles for seven C-type CpG islands in 105 gastric cancers. The DNA methylation status was examined using MSP or COBRA (see Figure 3). Patient numbers are indicated on the vertical columns and the seven CpG islands are indicated on the top row. +, DNMT1 protein overexpression-positive; −, DNMT1 protein overexpression-negative; solid box, methylated; open box, unmethylated; ND, not done. When DNA hypermethylation was seen in three or more CpG islands, the patient was regarded as being CIMP-positive.