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. 2005 Jan;166(1):253–263. doi: 10.1016/s0002-9440(10)62249-3

Figure 6.

Figure 6

α7BX2-mdx/utr−/− mice exhibit reduced cardiomyopathy. A: α7BX2-mdx/utr−/− mice have a fourfold reduction in the area of fibrotic lesions compared to mdx/utr−/− mice as evidenced by H&E staining of 8-week cardiac muscle (dashed outline). No lesions were observed in wild-type or mdx mice. B: Similarly, transgenic α7BX2-mdx/utr−/− mice showed a 10-fold reduction in the area of Evans blue dye uptake compared to mdx/utr−/−mice (arrows) and no dye uptake was observed in wild-type or mdx mice. C: Ventricular expression of ANF is an indicator of cardiomyopathy. RT-PCR analysis of ANF RNA shows that it is highly elevated in 8-week ventricular muscle of mdx/utr−/− mice and comparatively it is markedly reduced in α7BX2-mdx/utr−/− mice (P < 0.0002). All values are normalized to GAPDH.