Table 2.
List of the Main Genes Altered by Recurrent Cerulein-Induced Pancreatitis in Chronic Alcohol-Fed Rats
| Cy3/Cy5 signal | Accession No. | Gene names | |
|---|---|---|---|
| Apoptosis | |||
| Up-regulated | 498.1 | u72349 | Bcl-xbeta |
| 46.9 | u34932 | Fos-related antigen; FRA | |
| 23.4 | u40188 | Neuronal cell death-related gene in neuron-7 (DN-7); induced upon programmed cell death in neuronally differentiated PC12 cells | |
| 19.4 | u09793 | p21 (c-Ki-ras) | |
| 10.3 | s76513 | bcl-x = apoptosis inhibitor (protooncogene) (ovary, mRNA Partial, 726 (nt); apoptosis inhibitor | |
| 7.7 | l41275 | p21 protein (cip1) gene | |
| 6.9 | af136282 | Apoptotic death agonist BID (BID) | |
| 6.3 | af243515 | BCL2/adenovirus E1B 19 kd-interacting protein 3 (Bnip3); nuclear mitochondrial product; BNIP3; NIP3; pro-apoptotic mitochondrial | |
| 2.9 | af222733 | DEAD box protein 1 (Ddx1) partial cds | |
| 2.8 | u12187 | Ras-related protein (rad); ras-related protein | |
| Down-regulated | −3.3 | af239739 | Death-up-regulated gene (DUG) |
| −2.8 | ay029163 | BCL2L10 (Bcl2l10); Boo, Diva | |
| Cell growth and differentiation | |||
| Up-regulated | 109.7 | af002281 | Alpha-actinin-2 associated LIM protein; ALP |
| 99.5 | m74295 | rhoB gene | |
| 94.3 | af271786 | Fibroblast growth factor 13 (Fgf13) | |
| 85.9 | af036255 | RING finger protein; contains B-box, coiled-coil, ABP repeat, B-propeller, WD repeat, RBCC domain | |
| 79.0 | l13619 | Growth response protein (CL-6); insulin-induced | |
| 63.3 | af205717 | Tetraspan protein LRTM4 (LRTM4) | |
| 46.0 | af172174 | Urotensin II precursor | |
| 44.4 | x54806 | Cytokeratin type I (3′ end) | |
| 43.3 | s70803 | Clone p10.15 product (osteosarcoma ROS17/2.8, 737 (nt); | |
| 38.9 | u47673 | Sodium-cotransporter rkST1 partial cds; member of the SGLT1-transporter-family | |
| 37.8 | j03886 | Skeletal muscle myosin light chain kinase; skeletal muscle light chain kinase (E.C. 2.7.1.37) | |
| 34.4 | u61748 | Clone 9–32 (Rk9–32), dynein heavy chain (Dnchc2) partial cds; overlaps with GenBank accession no. D26495; molecular motor | |
| 33.3 | j02713 | Mast cell protease-like gene, 5′ end; homologue | |
| 32.7 | l09120 | Calpain II 80 kd subunit | |
| 27.1 | af028784 | Glial fibrillary acidic proteins alpha and delta (GFAP) gene, alternatively spliced products; intermediate filament; alternatively spliced | |
| 26.4 | m84685 | Muscle regulatory factor (MRF4) gene | |
| 26.0 | af272661 | Alpha 4 type V collagen; collagen alpha chain | |
| 24.3 | u46034 | Stromelysin 3 | |
| 22.6 | s54212 | Ciliary neurotrophic factor receptor alpha component (brain, 1332 (nt)) | |
| 22.6 | d14014 | Cyclin D1 | |
| 18.8 | af177694 | Protocadherin-T2 (pcdh-T2) partial cds; protocadherin gamma family member | |
| 16.3 | ab020022 | Neuronal differentiation-related; neuronal differentiation-related gene | |
| 16.5 | m83177 | Amyloid P component (SAP) | |
| 16.3 | ab020022 | Neuronal differentiation-related; neuronal differentiation-related gene | |
| 12.6 | l35271 | AML1 | |
| 12.2 | af014827 | Vascular endothelial growth factor D (VEGF-D) | |
| 10.6 | u66470 | Cell growth regulator rCGR11 | |
| 7.8 | m76535 | Gap junction structural protein, connexin (CXN-40) gene | |
| 6.3 | m92074 | Troponin I | |
| 5.9 | af016503 | Procollagen C-proteinase enhancer protein (PCPE) | |
| 5.9 | af178086 | Kidney-specific membrane protein NX-17 | |
| 5.9 | d83348 | Long-type PB-cadherin | |
| 5.9 | u05784 | Microtubule-associated proteins 1A and 1B light chain 3 subunit | |
| 5.7 | af077338 | Myosin-binding protein H; MyBP-H | |
| 3.4 | af311311 | P116RIP; Rho-interacting protein; similar to Mus musculus p116Rip | |
| Down-regulated | −2.2 | af236054 | Liver regeneration-related protein 1 |
| −2.4 | af277717 | Fibroblast growth factor receptor 3 (Fgfr3) | |
| −3.7 | af324043 | Claudin-11; tight junction protein | |
| −4.0 | u11031 | Neural cell adhesion molecule BIG-1 protein (BIG-1) | |
| −588.3 | m93005 | Guanylin; precursor | |
| (Table continues) |