Figure 6.

Effect of CCL28 antiserum on allergic lung inflammation. Mice were treated with anti-CCL28 or control serum 1 hour before challenge with intratracheal CRA and airway hyperresponsiveness (a) and peribronchial eosinophilia (b) were measured 8 or 24 hours later. As indicated, the dose of methacholine chosen for these studies induced minimal increases in control, unchallenged mice while inducing a significant response in allergen-challenged mice. Data are representative of three separate experiments and presented as mean ± SEM (n = 4 to 5 mice per treatment group; P < 0.05).