Figure 4.

Effect of reduced FAK expression on dynamic cell adhesion to ECM. HT-29 cells treated with FAK antisense or mismatch-control oligonucleotides were used for adhesion assays in a laminar flow chamber. BSA was used as nonspecific adhesion substrate. Values are shown as mean ± SD from five different experiments. Numbers of adherent cells were compared to dynamic adhesion of untreated cells to C I using Student’s t-test (#, P < 0.05). Similar results were obtained using C IV as adhesive substrate.