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. 2005 Mar;166(3):811–822. doi: 10.1016/S0002-9440(10)62302-4

Figure 2.

Figure 2

Cytokine production. Abortion mice produced significantly less IL-10 (A) and presented therefore a statistically significant diminution in the IL-10/TNF-α ratio when compared to normal pregnant mice (B, P < 0.05) as analyzed by the nonparametric Mann-Whitney U-test (P < 0.05). The IL-4/IFN-γ (C) ratio was slightly but not significantly diminished as analyzed in decidual cells after ex vivo stimulation with PMA/ionomycin. The data are presented as median ± 75% quartiles. D and E: Ag-specific cytokine production. Decidual (D) but not spleen (E) cells from abortion mice secreted more IFN-γ when stimulated with male APCs compared to normal pregnant mice (P < 0.001). IFN-γ production was analyzed in pooled decidual (D) or spleen (E) immune cells from at least three normal pregnant or abortion mice when co-cultured with CBA/J antigen (syngeneic control) or male antigens (BALB/c or DBA/2J). The data are representative of two independent experiments. Statistical significances were analyzed by the χ2 test and α-adjusted by Bonferroni’s test.