Table 1.

Immunohistochemical Analysis of IL-27 Expression in HL

Case no.	Diagnosis	Site	LMP1 status	% of EBI3+ HRS cells	% of p28+ HRS cells
1	NS	Lymph node	pos	++++	−
2	NS	Lymph node	pos	++++	+
3	NS	Lymph node	neg	++++	−
4	NS	Lymph node	neg	++++	+
5	NS	Lymph node	neg	++++	+
6	NS	Mediastinum	neg	++++	−
7	NS	Mediastinum	neg	++++	−
8	LD	Lymph node	pos	++++	+
9	LD	Lymph node	neg	++++	−
10	MC	Lymph node	pos	++++	−
11	MC	Lymph node	pos	++++	+
12	uc	Lymph node	pos	++++	−
13	NLP	Lymph node	neg	++++	−
14	NLP	Lymph node	neg	++++	−

NS, nodular sclerosis; LD, lymphocyte depletion; MC, mixed cellularity; uc, unclassified; NLP, nodular lymphocyte predominant. 

⁻, virtually all cells negative; 

⁺, 1 to 5% positive cells; 

⁺⁺⁺⁺, >90% positive cells.