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. 2005 Apr;166(4):1121–1130. doi: 10.1016/S0002-9440(10)62332-2

Figure 1.

Figure 1

PNA histochemical analysis of biopsied skeletal muscle tissues. A: Transverse cryosections of muscle biopsy specimens from normal controls (N1 and N2), an OPMD patient, and DMRV patients (DMRV-1, DMRV-2, DMRV-3, DMRV-4, DMRV-5B, and DMRV-5S-1) were stained with rhodamine isothiocyanate-labeled PNA. PNA-reactive glycoconjugates are localized in the sarcolemma in DMRV skeletal muscles but not in normal skeletal muscles. B: Transverse cryosections of muscle biopsy specimens from a DMRV patient (DMRV-5S-2), a MD patient, an EDMD patient, and a normal control (N3) were co-stained with PNA lectin and an antibody against dystrophin. The merged images show that PNA-reactive materials were co-localized with dystrophin in the DMRV patient, although PNA reactivity was also observed in connective tissues of the DMRV, MD, EDMD, and normal control. Scale bars: 50 μm (A); 20 μm (B).