Figure 6.

T lymphocytes are necessary for pathogenicity of vasculitic serum. Serum collected and pooled from wt BALB/c mice with vasculitis was transferred to either RAG2^−/− or JhD mice intravenously. A: Incidence of vasculitis in RAG2^−/− BALB/c mice after transfer of wt BALB/c vasculitic serum, as compared to transfer of control healthy mouse serum (n = 6 mice per group). B: Incidence of vasculitis in JhD BALB/c mice after transfer of wt BALB/c vasculitic serum, as compared to transfer of control healthy mouse serum (n = 3 mice per group). Each circle represents the vasculitis incidence for one recipient mouse; the horizontal bar depicts the average incidence of vasculitis lesions in a particular experimental group of mice; *P < 0.05 (Student’s t-test). Results from three experiments are presented.