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. 2005 Jun;166(6):1637–1645. doi: 10.1016/s0002-9440(10)62474-1

Figure 4.

Figure 4

TNF-α dose and TRAF1-dependent increase in serum aminotransferase and TNF-α levels. AST (A) and ALT (B) were measured in serum isolated by intracardiac puncture from WT (gray bars) or TRAF1−/− (black bars) mice 20 hours after intratracheal treatment with increasing doses of rmTNF-α. *, P < 0.001 TRAF1−/− as compared to WT at same dose. For dose versus AST or ALT, R2 = 0.71 and 0.69, respectively, in TRAF1−/− and R2 < 0.3 in WT. Serum (C) and BAL (D) were assayed by mTNF-α ELISA, 20 hours after intratracheal treatment of WT (gray bars) and TRAF1−/− (black bars) mice with increasing doses of rmTNF-α. *, P < 0.01; #, P < 0.03 TRAF1−/− compared to WT at same TNF dose. Mean ± SEM, n = 7 to 11.