Figure 1.

Activation of NF-κB in skin specimens from inflammatory acne lesions. An inflammatory papule (B) and adjacent clinically normal skin (A) were obtained from acne patients. A component of NF-κB, p65 protein, was detected with biotinylated antibody in combination with Texas Red. p65 protein is stained red by this technique. A, inset, reveals cytoplasmic staining in a chicken-wire pattern in the epidermis, whereas B, inset, demonstrates a nuclear solid dot pattern. The specimens are from one subject and are representative of the findings in involved and uninvolved tissue from four patients.