Figure 10.

Schematic representation of the events occurring in experimental endotoxemia. The model proposed indicates a functional link between the proinflammatory phase of the local and systemic response to LPS, and the activation of the protective/anti-inflammatory phase. Based on the results presented here, highlighted is AnxA1 activation in resident cells (macrophages and epithelial cells, for instance) as well as in extravasated PMNs, a phenomenon that follows a precise time dependency and is crucial for animal survival. See Discussion for more details.