Table 1.

Annexin 1 Promoter Gene Activation in Mouse Organs during Endotoxemia

Organ	Localization	Basal	Time after LPS (hours)
			1.5	6	24
Lung	Epithelium	61 ± 9	29 ± 3*	108 ± 9*	37 ± 3
	Alveolar macrophage	55 ± 4	60 ± 4	85 ± 9*	52 ± 10
	Intravascular leukocyte	0	53 ± 3	61 ± 4	55 ± 5
	Extravasated leukocyte	0	0	105 ± 5	78 ± 3
Trachea	Epithelium	33 ± 3	36 ± 3	37 ± 3	210 ± 11*
Kidney	Glomerulum	22 ± 5	50 ± 3*	47 ± 3*	37 ± 5
Liver	Hepatocytes	0	25 ± 1	30 ± 3	38 ± 3

AnxA1-null mice received 10 mg/kg i.p. LPS at time 0, and organs were collected at the reported time points. Histological preparations and X-Gal staining were done as described in the Materials and Methods section. Values (densitometric units) are mean ± SEM of 10 tissue sections analyzed from five mice per group. 

^*P < 0.05 versus time 0.