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Space-filling model of the Epo B conformation shown in Fig. 2 A and C (carbon atoms in cyan) docked into an energy-refined model of tubulin. The backbone ribbon structure of tubulin is in light green and the M loop is in yellow. Two residues that confer resistance against epothilones are displayed as stick models. The carbon atoms of these residues are shown in light magenta for the wild type and in white for the mutants.
