Figure 3.
Alcohol-induced histopathological changes in the myocardium and the effect of zinc supplementation on the changes. Alcohol (EtOH) feeding markedly increased the size of cardiomyocytes in comparison with the controls (Cont) in both WT and MT-KO mice. Zinc (Zn) supplementation did not alter the morphology of the myocardium or affect the alcohol-induced hypertrophy of the cardiomyocytes (Zn/EtOH). Degenerative morphological changes including myocyte necrosis were identified in the alcohol-treated myocardium.