Figure 1.

Clinical course of EAE disease in tPA^−/− and uPAR^−/− mice. WT, tPA^−/− (A), and uPAR^−/− (B) mice were immunized with 300 μg of MOG 35-55 in complete Freud’s adjuvant on days 0 and 7 and injected with pertussis toxin on days 0 and 2 to induce EAE. All mice were scored for clinical signs of disease on a scale of 1 to 5. Results are plotted as the mean clinical score for all animals in each group; n = 19, WT (three of which failed to develop EAE); n = 14, tPA^−/−; and n = 14, uPAR^−/−. A: tPA^−/− mice incurred a more prolonged and severe disease characterized by an incomplete recovery. B: uPAR^−/− mice showed a delay in the onset and peak of disease.