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. 2005 Oct;167(4):1093–1103. doi: 10.1016/S0002-9440(10)61198-4

Figure 9.

Figure 9

Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling. A: In normal condition, activation of either pathway results in the phosphorylation of both p90 ribosomal S6 kinase 1 (RSK1) and Akt that, in turn, are capable of phosphorylating tuberin directly. This inhibits tuberin function and promotes mTOR-mediated signaling. B: In TSC2 cells, the loss of tuberin releases the regulation of mTOR and, likely, may lead to the modification of ERK-RSK1 function with direct/indirect regulation of mTOR. This may explain the EGF requirement for A+ cell proliferation.