Table 1.
Morphometric Analysis of WT and Lox−/− Lungs at E18.5
| WT | −/− | |
|---|---|---|
| Body weight (g) | 1.246 ± 0.157 | 1.161 ± 0.149NS |
| (n = 14) | (n = 18) | |
| Lung weight/body weight (g) | 0.0391 ± 0.006 | 0.0324 ± 0.006† |
| (n = 14) | (n = 18) | |
| Number of bronchioles/mm2 | 8.66 ± 1.97 | 6.67 ± 0.77* |
| (n = 6) | (n = 6) | |
| Number of distal airways/mm2 | 229.37 ± 8.00 | 180.31 ± 27.10‡ |
| (n = 6) | (n = 6) | |
| Number of arteries/mm2 | 15.93 ± 0.96 | 14.25 ± 2.48NS |
| (n = 6) | (n = 6) | |
| Thickness of the bronchial epithelium (μm) | 13.08 ± 1.15 | 11.75 ± 0.75‡ |
| (n = 33§) | (n = 25§) | |
| Number of epithelial cells in bronchioles (cells/mm) | 166.42 ± 17.94 | 153.52 ± 16.26† |
| (n = 32§) | (n = 25§) | |
| Thickness of the pulmonary arterial walls versus diameter (%) | 29.85 ± 4.93 | 31.44 ± 4.94NS |
| (n = 37§) | (n = 49§) |
*
P < 0.05;
†
P < 0.01;
‡
P < 0.001.
§
n refers to the number of bronchioles or arterioles calculated from randomly selected sections of three embryos. Otherwise n refers to the number of embryos included in the analysis.