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Bone degeneration after ET administration. Histopathological analysis of femur after intravenous injection with 37.5 μg of EF (control), PBS, or 37.5 μg of ET. a: Growth plate from femur of PBS control (24 hours). b and c: Loss of osteoblasts and osteocytes of the metaphyseal bone marrow at 24 (b) and 48 (c) hours after ET treatment. Inset: Lacunae containing necrotic osteocytes (solid arrows). E, epiphysis; GP, growth plate; M, metaphysis. Original magnifications: ×20; ×100 (inset).
