Table 1.

Neurodegenerative Diseases Linked to Impairments in Axonal Transport

Neurodegenerative disease	Mutant gene/disease protein
Hereditary spastic paraplegia	Kinesin heavy chain (Kif 5a)
Familial motor neuron disease	Dynactin p150 subunit
Charcot-Marie-Tooth disease type 2A	Kinesin Kif 1B β subunit
Huntington’s disease	Huntingtin
Familial amyotrophic lateral sclerosis	Superoxide dismutase 1
Parkinson’s disease and related synucleinopathies	α-synuclein
Alzheimer’s disease	APP, presenilins, tau
Neurodegenerative tauopathies	tau

This table summarizes neurodegenerative diseases potentially linked to impairments in axonal transport as well as their mutant or disease proteins (see Roy et al15 for further details and additional citations).