Table 2.
MT binding/stabilizng agents | Natural product source |
---|---|
Paclitaxel (Taxol) | Pacific yew bark |
Coumarins and dicoumarol | Diverse plant leaves |
Dictostatins | Marine sponges |
Discodermolides | Marine sponges |
Eleutherobin | Soft ocean coral |
Sarcodictyins A and B | Soft ocean coral |
Epothilones A and B | Myxobacteria |
Laulimalides | Marine sponges |
Peloruside | Marine sponges |
Taccalonolides | Tiger whisker plant |
Tubercidin | Marine sponges, bacteria |
This table lists a number of representative MT-binding/stabilizing compounds and the natural products from whence they are derived (see Trojanowski et al23 for further discussion and additional citations).