Abstract
High concentrations of thyroid-stimulating hormone (TSH) in the serum have often been reported in apparently euthyroid patients with damaged thyroids. We have confirmed this finding in 14 patients 18 months after subtotal thyroidectomy for Graves's disease (group 1) and in 14 patients with manic-depressive psychosis (group 2) receiving lithium carbonate, which reduces thyroid reserve. One factor common to groups 1 and 2 but not to the controls was reduced thyroid reserve or functioning capacity, and, using established physical principles of servo-control, we have tried to define the mechanism. A series of curves were projected to indicate how TSH might be expected to vary with functioning thyroid capacity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gordin A., Saarinen P., Pelkonen R., Lamberg B. A. Serum thyrotrophin and the response to thyrotrophin releasing hormone in symptomless autoimmune thyroiditis and in borderline and overt hypothyroidism. Acta Endocrinol (Copenh) 1974 Feb;75(2):274–285. doi: 10.1530/acta.0.0750274. [DOI] [PubMed] [Google Scholar]
- Hennemann G., Van Welsum M., Bernard B., Docter R., Visser T. J. Serum thyrotrophin concentration: an unreliable test for detection of early hypothyroidism after thyroidectomy. Br Med J. 1975 Oct 18;4(5989):129–130. doi: 10.1136/bmj.4.5989.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Himsworth R. L., Fraser P. M. Grades of hypothyroidism. Br Med J. 1973 Aug 4;3(5874):295–295. doi: 10.1136/bmj.3.5874.295-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reichlin S., Martin J. B., Mitnick M., Boshans R. L., Grimm Y., Bollinger J., Gordon J., Malacara J. The hypothalamus in pituitary-thyroid regulation. Recent Prog Horm Res. 1972;28:229–286. [PubMed] [Google Scholar]
- Seth J., Toft A. D., Irvine W. J. Simple solid-phase radioimmunoassays for total tri-iodothyronine and thyroxine in serum, and their clinical evaluation. Clin Chim Acta. 1976 May 3;68(3):291–301. doi: 10.1016/0009-8981(76)90394-6. [DOI] [PubMed] [Google Scholar]
- Toft A. D., Hunter W. M., Barnes E. W., Seth J., Irvine W. J. Raised plasma-thyroid-stimulating-hormone levels in thyrotoxic patients treated with iodine-131. Lancet. 1973 Sep 22;2(7830):644–645. doi: 10.1016/s0140-6736(73)92481-1. [DOI] [PubMed] [Google Scholar]
- Vale W., Burgus R., Guillemin R. Competition between thyroxine and TRF at the pituitary level in the release of TSH. Proc Soc Exp Biol Med. 1967 May;125(1):210–213. doi: 10.3181/00379727-125-32051. [DOI] [PubMed] [Google Scholar]
- Vanhaelst L., Bastenie P. A. Test à la TRH dans l'hypothyroïdie latente. Nouv Presse Med. 1975 Jun 14;4(24):1813–1813. [PubMed] [Google Scholar]