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COX catalyzes the conversion of AA to PGH2. Cell-specific synthases and isomerases catalyze the transformation of PGH2 into other PGs or Tx that exert biological activity by binding to specific cell surface receptors. Alternatively, PGH2 may rearrange to form LGs, γ-ketoaldehydes that irreversibly form adducts with protein lysyl groups and lead to protein-protein crosslinking.
