Table 3.
Dosage of Am580 (mg/kg body weight) | 0 | 10 | 50 | 100 | 125 |
Number of litters examined | 7 | 6 | 9 | 6 | 6 |
Number of fetuses that underwent resorption | 1 | 8 | 11 | 10 | 12 |
(% total fetuses) | (1) | (14) | (10) | (15) | (21) |
Number of live fetuses | 82 | 51 | 99 | 56 | 45 |
% Live fetuses with any renal malformation | 0 | 6 | 62 | 89 | 100 |
% Live fetuses with bilateral renal agenesis | 0 | 0 | 0 | 18 | 47 |
% Live fetuses with unilateral renal agenesis* | 0 | 0 | 7 | 16 | 24 |
% Live fetuses with nonagenesis renal malformations† | 0 | 6 | 55 | 55 | 29 |
Contralateral kidney either normal or with nonagenesis renal malformations.
Bilateral or unilateral with contralateral kidney being normal.