Table 3.

Effect of Treatment with Various Dosages of Am580 at 9 Days 0 Hours on Kidney Development Assessed at E18

Dosage of Am580 (mg/kg body weight)	0	10	50	100	125
Number of litters examined	7	6	9	6	6
Number of fetuses that underwent resorption	1	8	11	10	12
(% total fetuses)	(1)	(14)	(10)	(15)	(21)
Number of live fetuses	82	51	99	56	45
% Live fetuses with any renal malformation	0	6	62	89	100
% Live fetuses with bilateral renal agenesis	0	0	0	18	47
% Live fetuses with unilateral renal agenesis*	0	0	7	16	24
% Live fetuses with nonagenesis renal malformations†	0	6	55	55	29

^*Contralateral kidney either normal or with nonagenesis renal malformations. 

^†Bilateral or unilateral with contralateral kidney being normal.