Table 4.

Comparison on Susceptibility of Wt1 Mutant and Wild-Type Embryos to RA-Induced Renal Malformations Assessed at E18

Dosage of RA (mg/kg body weight)	50
Number of litters examined	8
Number of fetuses that underwent resorption	0
Genotype	Wt1(+/+)	Wt1(+/−)
Number of live fetuses	36	33
% Live fetuses with any renal malformation	6	21
% Live fetuses with bilateral renal agenesis	0	0
% Live fetuses with unilateral renal agenesis*	0	12
% Live fetuses with nonagenesis renal malformations†	6	9

^*Contralateral kidney either normal or with nonagenesis renal malformations. 

^†Bilateral or unilateral with contralateral kidney being normal.