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Effect of CCL2 on APP processing in vitro. Nerve growth factor-treated differentiated PC12 cells (1 × 105 cells/well in poly-d-lysine-coated 24-well plate) were infected with recombinant adenovirus expressing Swedish FAD APP695 mutant11 and subsequently stimulated with increasing doses of recombinant murine CCL2 for 24 hours. Media was collected and both Aβ40 and Aβ42 levels were determined by specific Aβ ELISA. Data were presented as pg/ml, ng/ml, or percent ratio of Aβ42/Aβ40.
