Table 1.

Morphological Analysis of the GA in Hippocampal Neurons Transfected Either with GFP, GFP-Tau 4R, GFP-P301L, GFP-R406W, or GFP-V337M

	Number of cells examined	Percentage of cells with a fragmented GA	SEM
GFP	167	6.5	0.4
GFP-Tau 4R	162	30.89*	1.7
GFP-P301L	166	39.01*	2.3
GFP-R406W	168	41.04*	0.52
GFP-V337M	164	42.68*	0.72

The number of cells with a fragmented GA was significantly higher in neurons expressing wild-type human tau4R than in GFP-expressing neurons. The percentage of neurons expressing a mutant form of tau4R (P301L, V337M, or R406W) with a fragmentation of the GA was significantly higher than in wild type tau4R-expressing neurons. The statistical significance between the different groups was determined by using a one-way analysis of variance followed by the Tukey-Kramer multiple comparison post hoc test. 

^*P < 0.001.