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. 2005 May;166(5):1523–1532. doi: 10.1016/S0002-9440(10)62368-1

Figure 3.

Figure 3

Reduced cell proliferation in bid-deficient livers soon after DEN administration. A: Fifteen-day-old wild-type mice (open bar) were treated with DEN. Three and 10 days later, these mice and their non-treated age-matched littermates (gray bar) were injected with BrdU and sacrificed. BrdU incorporation in the liver was determined by anti-BrdU immunohistochemical staining and BrdU positive cells were counted in high power fields (×200). At least five fields were counted for each of the three mice in each group. B: DEN-treated 15-day-old bid-deficient mice (closed bar) and their non-treated age-matched littermates (gray bar) were analyzed in the same way as the wild-type mice. C: Comparison of BrdU incorporation in wild-type (open bar) and bid-deficient (closed bar) mouse livers at 3 days and 10 days after DEN treatment. Significant increase of BrdU incorporation could be detected in treated wild-type livers by day 10 (A) but not in bid-deficient (B) livers and the difference between the treated wild-type and bid-null mice are significant (C). The P values are based on Student’s t-test.