Table 7.
Distribution of the Differentially Expressed Genes in Metastasis-Related Groups Generated from the Horizontal and Vertical Comparisons in Vivo and from the Cell Line Comparisons in Vitro
In vivo | Genes up-regulated
|
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nonmetastatic tumor
|
Metastatic tumor
|
Lung metastases
|
LN metastases
|
|||||||||||
Compared samples | fc | P < 0.001 | P < 0.005 | P < 0.05 | P < 0.001 | P < 0.005 | P < 0.05 | P < 0.001 | P < 0.005 | P < 0.05 | P < 0.001 | P < 0.005 | P < 0.05 | |
NM-2C5T | M-4A4T | fc > 1.5 | 142 | 386 | 1068 | 219 | 416 | 697 | ||||||
fc > 3 | 17 | 43 | 92 | 55 | 77 | 101 | ||||||||
NM-2C5T | M-4Lu | fc > 1.5 | 117 | 323 | 969 | 193 | 403 | 660 | ||||||
fc > 3 | 12 | 31 | 82 | 51 | 74 | 90 | ||||||||
NM-2C5T | M-4LN | fc > 1.5 | 114 | 329 | 886 | 190 | 379 | 680 | ||||||
fc > 3 | 15 | 35 | 87 | 48 | 67 | 95 | ||||||||
M-4A4T | M-4Lu | fc > 1.5 | 1 | 9 | 69 | 2 | 17 | 88 | ||||||
fc > 3 | 0 | 0 | 6 | 1 | 2 | 8 | ||||||||
M-4A4T | M-4LN | fc > 1.5 | 14 | 56 | 279 | 14 | 58 | 184 | ||||||
fc > 3 | 2 | 8 | 27 | 3 | 9 | 17 | ||||||||
M-4Lu | M-4LN | fc > 1.5 | 4 | 14 | 50 | 0 | 1 | 20 | ||||||
fc > 3 | 1 | 1 | 4 | 0 | 0 | 0 |
In vitro | Nonmetastatic line | Metastatic line | Highly metastatic line | ||
---|---|---|---|---|---|
NM-2C5 | M-4A4-GFP | fc > 1.5 | 363 | 361 | |
fc > 3 | 40 | 28 | |||
NM-2C5 | LM3 clone 16 | fc > 1.5 | 1708 | 930 | |
fc > 3 | 198 | 113 | |||
M-4A4-GFP | LM3 clone 16 | fc > 1.5 | 1473 | 336 | |
fc > 3 | 155 | 70 |