Table 1.

Measurements of Pneumocystis-Related Pulmonary Pathology in μMT and Wild-Type Mice with CD4 T-Cell Depletion

Parameter	μMT	WT-CD4	μMT-CD4	Control
Respiratory rate (breaths/minute)	520.0 ± 11.7 (4)	505.2 ± 14.4 (5)	441.6 ± 17.9 (5)	316.1 ± 10.1 (5)
PaO2 (mmHg)	42.33 ± 2.55 (4)*	63.72 ± 2.16 (5)	54.78 ± 4.37 (4)	87.40 ± 0.72 (5)
BAL albumin (mg/ml)	0.098 ± 0.01 (4)	0.13 ± 0.03 (4)	0.13 ± 0.04 (5)	0.01 ± 0.01 (5)
BAL LDH (U/ml)	0.125 ± 0.034 (4)	0.195 ± 0.062 (4)	0.100 ± 0.008 (4)	0.060 ± 0.008 (4)

μMT and wild-type (WT; C57BL/6) mice were inoculated with 10⁷ Pneumocystis organisms. −CD4 groups were depleted of CD4⁺ cells with twice weekly injections of GK1.5. Control mice were neither inoculated nor depleted. Twenty-eight days after inoculation, respiratory rates were measured and arterial blood was sampled for measurement of O₂ partial pressure (PaO₂). Mice were sacrificed and bronchoalveolar lavage (BAL) performed to obtain samples for measurement of albumin and LDH. Values are means ± SEM (n). 

^*Indicates value is significantly different from all other groups in same row (P < 0.05).