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. 2006 Mar;168(3):737–747. doi: 10.2353/ajpath.2006.050656

Figure 8.

Figure 8

Fibronectin deposition in the kidneys of DEX-treated animals is mediated by CTGF. DEX increased the mRNA expression of CTGF and FN-EIIIA in the kidneys of C57B6 (A) and SJL mice (B) after 12 hours. A: Co-treatment with DEX and CTGF-AS significantly inhibited DEX-induced CTGF and FN-EIIIA mRNA expression in the kidneys of C57B6 mice, but there were no significant effects by co-treatment with CTGF-mAS. B: DEX decreased CTGF and FN-EIIIA mRNA levels in the kidneys of SJL mice regardless of co-treatments. C: Minimal deposition of fibronectin protein (arrows) was seen in control C57B6 mouse kidneys (C57-NC). D: C57B6 mice that were treated for 2 weeks with DEX and CTGF-mAS (C57-mAS) displayed fibronectin protein deposition in their kidneys (arrows). E: In contrast, co-treatment of C57B6 mice with CTGF-AS (C57-AS) suppressed DEX-induced fibronectin protein deposition (arrows). Each of the data in A and B was obtained from four mice, and data in C to E are representative of the sections obtained from four mice in each case. DAB stain. Original magnifications, ×100.