Figure 1.

Expression of insulin signaling molecules in skin repair. Regulation of InsR (A) and Glut-4 (B) mRNA expression in nonwounded back skin (ctrl) and wound tissue isolated from wild-type (C57BL/6) and ob/ob mice. The time after injury is indicated. Each single experimental time point represents 16 wounds (n = 16) isolated from four individual mice of two experimental series. Mean expression levels during repair are shown in the right panels. **, P < 0.01; *, P < 0.05. Bars indicate the mean ± SD over the healing period (days 1 to 13) from 80 wounds from 20 animals.