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. 2006 Mar;168(3):796–804. doi: 10.2353/ajpath.2006.050496

Figure 6.

Figure 6

JHMV infection induced CNS inflammation and demyelination. Spinal cords from Wt (A, C, and E) and Tg mice (B, D, and F) 18 days p.i stained with H&E (A and B) or luxol fast blue (C and D). Extensive white matter inflammation associated with demyelination in both Wt (A and C) and Tg mice (B and D). Axons within the demyelinated lesions in Wt (E) and Tg (F) mice were visualized with anti-phosphoneurofilament antibody. Scale bar = 100 μm. Co-localization of viral antigen in oligodendrocytes (G) is shown, using virus-specific mAb J.3.3 (red) and anti-adenomatus ployposis coli (gray) at 18 days p.i. Scale bar = 50 μm. The inset shows higher magnification of double-positive cells in spinal cord of Tg mice.