Figure 5.
AT1 receptor mediates Ang II-induced ZO-1 redistribution and permselective dysfunction. a and b: Micrographs show ZO-1 redistribution in podocytes exposed to Ang II (b) compared with control (a). c: L-158,809 prevented changes in ZO-1 staining in podocytes on Ang II exposure. d: Transepithelial albumin permeability in control (open bar) and Ang II-stimulated podocytes in the absence (gray bar) or presence (hatched bar) of AT1 receptor blocker L-158,809. Data are means ± SEM of six independent experiments, *P < 0.01 versus control; °P < 0.01 versus Ang II.