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. 2006 May;168(5):1686–1696. doi: 10.2353/ajpath.2006.050859

Figure 3.

Figure 3

Early exposure to cetuximab restores axon-glial interactions. A–D: Electron micrographs of saphenous nerves from 3-month-old animals. A: WT nerves showed characteristic groups of small unmyelinated axons clustered within single nonmyelin forming Schwann cells. B: Untreated CNPase-hEGFR nerves were disrupted; nonmyelinating Schwann cells rarely wrap multiple axons. C and D: CNPase-hEGFR nerves treated with cetuximab beginning at birth for 2 weeks (C) or 6 weeks (D) showed WT levels of nerve organization; nonmyelinating Schwann cells were able to wrap multiple small axons. E: Quantification of percentage of grouped axons in nerves from WT, untreated CNPase-hEGFR (EGFR+), CNPase-hEGFR mice treated from birth for 2 weeks (0 × 2), birth to 6 weeks (0 × 6), 6 to 8 weeks (6 × 2), or 6 to 12 weeks (6 × 6) of age. Small axons are considered grouped if three or more are wrapped by a single nonmyelinating Schwann cell. Untreated CNPase-hEGFR nerves were significantly more disrupted than WT. CNPase-hEGFR nerves treated with cetuximab beginning at birth did not differ significantly from WT. Original magnifications, ×9375.