Figure 4.

Micrographs demonstrating the dramatic prevention of neuronal loss with transgene suppression. A and B: Suppression of the P301L tau transgene with dox for 6 weeks, from 4 to 5.5 months of age, prevented further neuron loss in CA1 without significantly affecting neurofibrillary pathology. C and D: Similarly, the drastic early loss of neurons in DG between birth and 2.5 months could be prevented completely by transgene suppression implying that the neuronal loss is degenerative instead of developmental. Scale bars, 100 μm. *, P < 0.01; t-test.