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Summary of the eight Cav-1 mutations identified in ERα-positive breast cancer samples. The full-length sequence (178 amino acids) of human Cav-1 is shown. The membrane-spanning domain (33 amino acids, residues 102–134) is highlighted in red. Mutations are indicated in bold. Note that 5 of the 7 mutated residues identified cluster within a 14-amino acid region (boxed). This “hot spot” is located near the C-terminal end of the membrane-spanning domain.
