Table 2.

Cav-1 Mutation Incidence in ER (+) and ER (−) Patients

Summary of age, stage, and time to first relapse of the 55 patients examined. Note that 32 cases were ERα-positive (+) and 23 cases were ERα-negative (−). Interestingly, Cav-1 mutations (P132L and others) were identified only in ERα (+) patients.

Characteristics		ER (+)	ER (−)	Significance
Patients (n)		32	23
Age (yrs)	Mean	58.2	54.0	P ≤ 0.24*
	Median	57.7	53.0
	Range	31.1–83.7	38.1–70.8
AJCC stage†	1	4	4	P ≤ 0.139*
	2A	14	11
	2B	4	2
	3A	3	2
	3B	3	0
	4	2	4
	Unknown	1	0
Time to first relapse (months)	Median	30.1	29.0	P ≤ 0.4*
	Range	3.2–60.1	8.8–51.4
Cav-1 (P132L) status	# Pos. (%)	6 (18.8%)	0 (0%)	P ≤ 0.03‡§
Other Cav-1 mutations	# Pos. (%)	5 (15.6%)	0 (0%)	P ≤ 0.05‡§
Total	# Pos. (%)	11 (34.4%)	0 (0%)	P ≤ 0.001‡§

^*Student’s t-test. 

^†AJCC, American Joint Committee on Cancer Staging. 

^‡Fisher’s exact test. 

^§Indicates statistical significance.