Table 3.
Characteristics of Cav-1 (P132L) (+) Patients
Summary of age, stage, and time to first relapse of the 55 patients examined. Note that 32 cases were ERα-positive (+) and 23 cases were ERα-negative (−). Interestingly, Cav-1 mutations (P132L and others) were identified only in ERα (+) patients.
| Patient | Age (yrs)* | AJCC stage | Recurrence type | P132L | C133R | Other mutations |
|---|---|---|---|---|---|---|
| 1 | 34.4 | 1 | Local | WT >P132L | None | W128Stop (TGG → TAG) |
| 2 | 63.2 | 2A | Unknown | WT >P132L | None | |
| 3 | 67.9 | 2A | Distant | P132L >WT | WT >C133R | Y148H (TAT → CAT) |
| 4 | 56.2 | 2A | Regional | WT >P132L | None | |
| 5 | 46.6 | 3A | Local & Distant | WT >P132L | None | |
| 6 | 73.0 | 3B | Distant | P132L >WT | WT >C133R | |
| Mean | 56.9 | |||||
| Median | 59.7 | |||||
| Range | 34–73 |
*
Age at diagnosis.