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Phospho-ERK1/2 immunohistochemistry of mouse glomeruli. a: Increased nuclear staining of phospho-ERK1/2 is observed in the male ACE2−/y mouse glomerulus, compared to male ACE2+/y, ARB-treated male ACE2−/y, and female ACE2−/− mouse glomeruli (magnification, ×600). b: Quantitative score of phospho-ERK1/2-positive nuclei per glomerular cross-section in the four groups of mice. *P < 0.01 versus ACE2+/y, ARB-treated ACE2−/y, and female ACE2−/− mice.
