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Cellular proliferation and type I procollagen production in monolayer culture. Proliferation (A) and type I procollagen production (B) by fibroblasts isolated from young and old skin. Values shown are averages ± SEM, based on 26 fibroblast isolates from eight young individuals and 37 isolates from eight old individuals. Statistical significance of the differences between isolates from young and old skin was determined using Student’s t-test. *Significance at the P < 0.05 level.
