Figure 1-6870.

Spontaneous morbidity and mortality of Nrf2 knockout mice. Female and male Nrf2 knockout mice (Nrf2^−/−) and wild-type control mice (Nrf2^+/+) were individually barrier-maintained in an environmentally controlled facility. Morbidity and mortality were examined and recorded daily. A: Morbidity. B: Survival over time. Genotype and gender are indicated. x axis indicates the ages of the mice in weeks. Animals in the study: wild type, 10 male and 10 female; Nrf2^−/−, 24 male and 14 female. Morbidity reflects a broad range of signs of illness as described in Results. Survival is based on spontaneous deaths and euthanasia of moribund mice.