TAble 2.

Stereological Analysis of 180-Day-Old VP following Neonatal DES

	Compartmental volume (mm3)
		Epithelium	Stroma	Lumen
WT control	2.10 ± 0.12	1.44 ± 0.16	6.83 ± 0.85
WT + DES	1.61 ± 0.30*	1.49 ± 0.33	0.94 ± 0.14*†
ArKO control	3.07 ± 0.41†	2.12 ± 0.34	11.84 ± 1.66†
ArKO + DES	2.75 ± 0.22†‡	2.53 ± 0.43†‡	3.74 ± 0.60*†‡

Compared to WT control tissue significant volumetric increases were detected in epithelial and luminal compartments (P < 0.05) of ArKO control VP, and a nonsignificant increase in stromal volume (P = 0.0778). After neonatal DES treatment, WT and ArKO stromal and epithelial volumes were not altered (compared to their respective controls), but luminal volumes were significantly reduced (P < 0.05 respectively; vs. controls). DES-treated ArKO volumes remaining significantly higher than in DES-treated WT and were significantly larger than WT controls (P = 0.05). Data are expressed as mean ± SE; n = 5–8. 

^*Significant comparison (P < 0.05) versus ArKO control. 

^†Significant comparison (P < 0.05) versus WT control. 

^‡Significant comparison (P < 0.05) versus WT DES.