Table 1.
BAC-derived recombinant virus | ICP4 expression cassette on the vector | Shuttle vector | Integrated pM24-BAC-shuttle clone | Description |
bM24-CMV | pFLS-CMV | pM24-BAC-CMV | The CMV promoter drives the ICP4 expression. | |
bM24-null | pFLS-ICP4 | pM24-BAC-null | No active promoter drives the ICP4 expression. | |
bM24-empty | NONE | pFLS2 | pM24-BAC-empty | No ICP4 CDS included on the vector. (A shuttle vector containing no ICP4 CDS was constructed) |
bM24-BAC | N/A | N/A | pM24-BAC (Non-integrated prototype HSV-BAC) | Genetically identical to the prototype HSV-BAC virus M24-BAC |
(N/A: not applicable)