Skip to main content
. 2006 Oct 17;4(11):e340. doi: 10.1371/journal.pbio.0040340

Figure 6. Autoantibodies and Arthritis Do Not Develop in the Presence of Polyclonal Endogenous T Cells.

Figure 6

(A–C) 3 million Ly5.1+,5C.C7 T cells were transferred into mPCC+/+ (T cell–replete) mice that had an intact repertoire of polyclonal T cells. Serum antibody titers were measured at various days after transfer. Total IgG1 (A), IgG2a (B), and IgG2b (C) levels are shown (filled circles). Inverted open triangles represent titers before T cell transfer. Data are pooled from two separate experiments with two to five mice per time point. Similar results were obtained in two other experiments.

(D–F) Serum from T cell–replete (F) or T cell–deficient (E) PCC transgenic mice were used to stain tester B10.A,Rag2−/− kidney sections at 1:100 dilution. Staining with control serum from a normal B10.A mouse is shown in (D).

(G) Development of arthritis scored in the T-replete mPCC transgenic, 5C.C7 transfer recipients.