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The number of positively selected sites in different functional domains of S protein.
| Functional domain | 02–04 interspecies epidemic group | 03-early-mid epidemic group | Fisher's exact test (p) |
| RBD | 6 | 1 | |
| HR1–HR2 | 1 | 4 | 0.045455 |
| HR2 | 0 | 3 | 0.033333 |
The Fisher's exact test was performed for HR1–HR2 vs. RBD, and HR2 vs. RBD, respectively.
