Table 3.
Visual Acuity in the Amblyopic Eye at the 5-Week Masked Outcome Examination Primary Cohort
| Overall | Baseline Amblyopic Eye Acuity |
|||||
|---|---|---|---|---|---|---|
| 20/40 to 20/100 | 20/125 to 20/400 | |||||
| Patching N=85 | Control N=88 | Patching N=71 | Control N=71 | Patching N=14 | Control N=17 | |
| Lines Change from Baseline n(%) | ||||||
| <=−3 | 2 (2) | 3 (3) | 1 (1) | 2 (3) | 1 (7) | 1 (6) |
| −2 | 2 (2) | 5 (6) | 2 (3) | 5 (7) | 0 | 0 |
| −1 | 5 (6) | 15 (17) | 5 (7) | 12 (17) | 0 | 3 (18) |
| 0 | 20 (24) | 22 (25) | 16 (23) | 17 (24) | 4 (29) | 5 (29) |
| +1 | 18 (21) | 25 (28) | 15 (21) | 20 (28) | 3 (21) | 5 (29) |
| +2 | 26 (31) | 13 (15) | 22 (31) | 12 (17) | 4 (29) | 1 (6) |
| +3 | 8 (9) | 2 (2) | 8 (11) | 1 (1) | 0 | 1 (6) |
| +4 | 2 (2) | 0 | 1 (1) | 0 | 1 (7) | 0 |
| +5 | 2 (2) | 2 (2) | 1 (1) | 2 (3) | 1 (7) | 0 |
| >+5 | 0 | 1 (1) | 0 | 0 | 0 | 1 (6) |
| Mean (SD*) lines change | 1.1 (1.6) | 0.5 (1.7) | 1.1 (1.5) | 0.4 (1.5) | 1.2 (1.9) | 0.6 (2.1) |
| Distribution of Visual Acuity n(%) | ||||||
| <20/125 | 5 (6) | 10 (11) | 2 (3) | 0 | 3 (21) | 10 (59) |
| 20/125 | 4 (5) | 2 (2) | 0 | 0 | 4 (29) | 2 (12) |
| 20/100 | 6 (7) | 9 (10) | 2 (3) | 5 (7) | 4 (29) | 4 (24) |
| 20/80 | 9 (11) | 11 (13) | 8 (11) | 11 (15) | 1 (7) | 0 |
| 20/63 | 13 (15) | 14 (16) | 12 (17) | 13 (18) | 1 (7) | 1 (6) |
| 20/50 | 9 (11) | 14 (16) | 9 (13) | 14 (20) | 0 | 0 |
| 20/40 | 24 (28) | 16 (18) | 23 (32) | 16 (23) | 1 (7) | 0 |
| 20/32 | 11 (13) | 10 (11) | 11 (15) | 10 (14) | 0 | 0 |
| 20/25 | 4 (5) | 1 (1) | 4 (6) | 1 (1) | 0 | 0 |
| 20/20 | 0 | 1 (1) | 0 | 1 (1) | 0 | 0 |
| Mean (SD) logMAR† | 0.44 (0.22) | 0.51 (0.28) | 0.38 (0.17) | 0.41 (0.16) | 0.74 (0.19) | 0.93 (0.26) |
| Approximate Snellen Equivalent | 20/50-2 | 20/63 | 20/50+1 | 20/50 | 20/100-2 | 20/160-1 |
| Difference Between Treatment Groups in Mean logMAR Acuity, Adjusted for Baseline Acuity‡ | 0.07 | 0.06 | 0.08 | |||
| (95% Confidence Interval) | (0.02, 0.12) | (0.01, 0.11) | (−0.09, 0.25) | |||
| Mean (SD) Interocular Difference at Masked Exam (lines) | 4.1 (2.4) | 4.8 (2.9) | 3.4 (1.9) | 3.9 (1.9) | 7.3 (2.3) | 8.6 (3.2) |
*
SD = Standard Deviation
†
logMAR = logarithm of the minimum angle of resolution
‡
Adjusted for baseline visual acuity in analysis-of-covariance model. (overall P value = 0.006) A positive difference indicates that the patching group scores were better than control group scores.
2 patients in the patching group and 5 in the control group did not complete the 5-week masked exam