Table 4.
Best Measured Visual Acuity During Follow-up Primary Cohort
| Overall | Baseline Amblyopic Eye Acuity |
|||||
|---|---|---|---|---|---|---|
| 20/40 to 20/100 | 20/125 to 20/400 | |||||
| Patching N=84 | Control N=87 | Patching N=70 | Control N=72 | Patching N=14 | Control N=15 | |
| Improvement from Baseline to Best Measured Acuity in Amblyopic Eye n(%) | ||||||
| 0 lines (no improvement or worsened) | 16 (19) | 34 (39) | 13 (19) | 27 (38) | 3 (21) | 7 (47) |
| 1 line improvement | 16 (19) | 22 (25) | 13 (19) | 18 (25) | 3 (21) | 4 (27) |
| 2 lines improvement | 19 (23) | 15 (17) | 18 (26) | 13 (18) | 1 (7) | 2 (13) |
| 3 lines improvement | 15 (18) | 12 (14) | 14 (20) | 11 (15) | 1 (7) | 1 (7) |
| ≥4 lines improvement | 18 (21) | 4 (5) | 12 (17) | 3 (4) | 6 (43) | 1 (7) |
| Mean (SD*) lines improvement | 2.2 (1.8) | 1.3 (1.4) | 2.1 (1.6) | 1.3 (1.3) | 2.7 (2.3) | 1.2 (1.9) |
| Interocular Difference† at Visit of Best Measured Acuity n(%) | ||||||
| ≥ 6 lines | 13 (15) | 18 (21) | 6 (9) | 6 (8) | 7 (50) | 12 (80) |
| 5 lines | 11 (13) | 17 (20) | 9 (13) | 15 (21) | 2 (14) | 2 (13) |
| 4 lines | 11 (13) | 9 (10) | 9 (13) | 9 (13) | 2 (14) | 0 |
| 3 lines | 14 (17) | 20 (23) | 12 (17) | 20 (28) | 2 (14) | 0 |
| 2 lines | 14 (17) | 13 (15) | 13 (19) | 12 (17) | 1 (7) | 1 (7) |
| 1 line | 14 (17) | 9 (10) | 14 (20) | 9 (13) | 0 | 0 |
| <=0 lines (amblyopic eye same or better than sound eye) | 7 (8) | 1 (1) | 7 (10) | 1 (1) | 0 | 0 |
| Mean (SD) lines | 3.3 (2.3) | 4.2 (2.6) | 2.8 (1.9) | 3.3 (1.6) | 5.9 (2.5) | 8.3 (2.9) |
| Time to Visit of Best Measured Acuity n(%) | ||||||
| Baseline | 16 (19) | 34 (39) | 13 (19) | 27 (38) | 3 (21) | 7 (47) |
| 5 weeks (3 to 7) | 36 (43) | 37 (43) | 30 (43) | 32 (44) | 6 (43) | 5 (33) |
| 10 weeks (8 to 12) | 20 (24) | 10 (11) | 19 (27) | 7 (10) | 1 (7) | 3 (20) |
| 15 weeks (13 to 17) | 5 (6) | 4 (5) | 4 (6) | 4 (6) | 1 (7) | 0 |
| >17 weeks | 7 (8) | 2 (2) | 4 (6) | 2 (3) | 3 (21) | 0 |
| Difference Between Treatment Groups in Mean Best logMAR‡ Acuity, Adjusted for Baseline Acuity§ | 0.10 | 0.07 | 0.20 | |||
| (95% Confidence Interval) | (0.05, 0.14) | (0.02, 0.12) | (0.01, 0.39) | |||
*
SD = Standard Deviation
†
Interocular difference evaluated using better of sound eye at baseline or at visit of best measured amblyopic eye acuity
‡
logMAR = logarithm of the minimum angle of resolution
§
Adjusted for baseline visual acuity in analysis-of-covariance model. (overall P value < 0.001) A positive difference indicates that the patching group scores were better than control group scores.
3 patients in the patching group and 6 in the control group with incomplete follow up are not included