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. 2006 Sep 27;399(Pt 2):335–342. doi: 10.1042/BJ20060612

Figure 2. G2/M-specific activity of the cIAP2 promoter is mediated by the region containing CDE-like and CHR elements.

Figure 2

(A) Increased cIAP2 promoter activity during G2/M phase. A series of cIAP2-promoter-fragment- containing luciferase constructs were transfected into HeLa cells, and luciferase activity was analysed in cultures synchronized in G1/S phase or in G2/M phase as described in Figure 1(B). The G1/S phase- or G2/M phase-specific increase in luciferase activity is expressed as the fold increase relative to the luciferase activity detected in asynchronized cells. The results are expressed as the means±S.D. for three independent experiments. (B) Sequence analysis of the region (−93 downstream) mediating the cell cycle-regulated transcription of the cIAP2 gene (left-hand panel). The CDE-like element and a CHR element are indicated. The alignment of the CDE-like and CHR elements from the cIAP2 promoter with those of other cell cycle-regulated genes is also shown (right-hand panel).