Supplement Table 1.
Adjusted mean quantitative traits (±SD) among genotypes
| Polymorphisms | AA | AG | GG | p-value |
|---|---|---|---|---|
| Exon S/D7N (rs1880676) | ||||
| AAO* | 71.10±0.83 (55) | 72.17±0.33 (346) | 72.68±0.27 (516) | 0.14 |
| Disease duration** | 9.45±1.36 (12) | 10.20±0.53 (69) | 9.57±0.35 (124) | 0.57 |
| MMSE baseline† | 22.86±0.47 (87) | 21.99±0.20 (557) | 21.92±0.17 (775) | 0.21 |
| MMSE last† | 21.11±0.65 (67) | 19.50±0.27 (488) | 19.69±0.21 (687) | 0.08 (0.03)a |
| Exon 5/A120T (rs3810950) | ||||
| AAO* | 70.89±0.75 (54) | 72.19±0.33 (350) | 72.70±0.27 (520) | 0.07 (0.05)a |
| Disease duration** | 9.34±1.21 (13) | 10.27±0.54 (68) | 9.73±0.35 (120) | 0.59 |
| MMSE baseline† | 22.54±0.46 (95) | 21.84±0.20 (618) | 21.66±0.17 (857) | 0.20 |
| MMSE last† | 21.13±0.63 (71) | 19.57±0.26 (496) | 19.71±0.21 (693) | 0.08 (0.02)a |
| Intron 9/11604G>A (rs868750) | ||||
| AAO* | 72.81±0.81 (37) | 72.57±0.36 (295) | 72.36±0.26 (585) | 0.85 |
| Disease duration** | 8.55±0.90 (15) | 10.26±0.50 (58) | 9.85±37 (127) | 0.35 |
| MMSE baseline† | 21.02±0.90 (46) | 21.80±0.22 (470) | 21.98±1.16 (915) | 0.36 |
| MMSE last† | 18.17±0.94 (44) | 19.43±0.27 (417) | 19.93±0.20 (792) | 0.05 (0.05)a |
*
Adjusted for gender and APOE*4
**
Adjusted for gender, APOE*4 and AAO
†
Adjusted for age controls, AAO cases, disease status, gender and APOE*4
a
p-values in parentheses are for comparison between the AA and AG+GG genotypes
Number in parentheses indicate number of subjects in each genotype